The Health and Safety Commission (HSC) and the government have challenged Britain's top 350 companies to cut injuries and ill-health at work.
Their proposed three-point plan may be extended to all companies with more than 250 employees.
Injuries and illness at work cost the UK up to £18bn a year.
They are asking the big names in British industry to:
The HSC has issued guidance to help companies meet these objectives.
HSC chairman Bill Callaghan said: "This initiative is designed, as much as anything, to identify good practice, which we will recognise formally and seek to share throughout the industry as a whole."